C (PfROM4) specifically mediated shedding of the erythrocyte-binding antigen (EBA-175) (O'Donnell et al. 2006). Our analysis found that homologs of the rhomboids detected by Dowse and Soldati (2005) are also found in the three additional species we examined. Based on our phylogenetic analysis, there are from 5 to 8 homologs of rhomboid proteases present in the Plasmodium species. They can be divid