M6-D does not have the next Cys remains from your EC2 area, as well as the fourth TM website. Earlier operate from your class around the computer mouse button M6a implies that the last Cys residues (C162 along with C202) are very important with regard to mobile surface area phrase and for M6a function [12]. In the case of soar M6-D, the lack of the very last TM prevents correct EC2 foldable, resul